A long term test and comparison of these two brain boosters:
When looking for a high-quality nootropic, you'll likely come across NooCube from Wolfson Brands Ltd and Alpha Brain from Onnit Labs Inc. Both promise enhanced mental clarity, focus, and overall cognitive health. But how do they compare? In this head-to-head analysis, I will evaluate both supplements, look at the detail of their formulations, ingredients, dosages and the science behind their claims and brand promises. NooCube features a mix that includes Bacopa Monnieri, L-theanine, and LuteMax 2020. Alpha Brain uses proprietary blends like Onnit Flow and Onnit Focus, containing Vinpocetine and Pterostilbene. I will examine the evidence for their claims, test each supplement myself, and scientifically analyse their ingredient lists.
An introduction to NooCube and Alpha Brain:
My research into this area tells me that these days more and more people are looking for reliable ways to stay mentally sharp and focused [1]. Alpha Brain from Onnit Labs has gained substantial attention, especially after receiving high praise from Joe Rogan, a well-known podcaster [2]. This has made Alpha Brain one of the most recognized nootropic brands on the market. On the other hand, we have NooCube by Wolfson Brands Ltd. NooCube takes a very different approach, emphasizing product quality and affordability without relying on high-profile endorsements [3]. While their marketing strategies differ, the real point of interest for me lies in their formulations. NooCube features a blend of ingredients like Bacopa Monnieri which is well known for it’s cognitive benefits, and the powerful antioxidant Resveratrol, among others [4]. Alpha Brain, in contrast, utilizes its proprietary blends which means it has a blend of different ingredients with the dosage levels of each component undisclosed. These ingredients are items such as Onnit Flow and Onnit Focus, which include ingredients like Vinpocetine and Pterostilbene. Despite their different approaches, it’s clear for me that both supplements aim to enhance cognitive function. In this analysis, I will take a closer look at what each product offers, examining the science behind their ingredient lists, dosages, and the claims made by their manufacturers.
NooCube claims:
NooCube markets itself as an advanced cognitive enhancer, making bold claims about it’s benefits. The company states that users can significantly sharpen their focus, enhance problem-solving abilities, and boost memory and overall alertness [5]. It promises to protect eyes from 'screen fatigue' and reduce mental fog associated with tiredness. The brand highlights that it’s formula is well supported by scientific research. I have found that ingredients like Bacopa Monnieri and L-theanine are well-known in the nootropic world [6]. However, the important question for me is whether this blend of ingredients truly delivers on it’s promises and works in real life.
Alpha Brain Claims
Alpha Brain, developed by Onnit, positions itself as a way to improve mental performance [7]. The company paints a very enticing picture: imagine being so deeply focused on a task that you lose all sense of time! Alpha Brain claims to make this level of immersion a regular experience. According to them, enhancing alpha wave production and boosting neurotransmitter activity allows your brain to perform at it’s best. Their unique blends, like Onnit Flow and Onnit Focus, are designed to achieve this. So, given all of this I was really looking forward to trying it out. However, I found that Onnit's use of proprietary blends has sparked some debate. This approach, like quite a few supplements on the market, conceals the exact ingredients and their quantities, making it difficult for a reviewer like me to know precisely what I am consuming and to do a proper assessment. This is obviously the same for consumers too. I always find that this lack of transparency can be a big concern for those who seek clarity about what they put into their bodies [8]. A significant factor in Alpha Brain's reputation is it’s strong celebrity endorsements, most notably from Joe Rogan. Beginning in 2010, Onnit sponsored Rogan's podcast, which eventually led to a business partnership until Unilever's acquisition of Onnit in 2021. With Rogan's podcast reaching an average of 11 million listeners per episode, this collaboration has greatly enhanced Onnit's visibility and played a substantial role in Rogan's financial success.
Testing experience
NooCube
I began my test of NooCube's on an ordinary Monday morning. With a barrage of emails, meetings, and deadlines, I decided to try NooCube instead of reaching for a third cup of coffee by midday. The first noticeable change that I found was an increase in focus. Previously, multitasking often led to overlooked details and minor errors. With NooCube, I found that each task became a point of intense concentration, likely due to Bacopa Monnieri [9], an adaptogen known for enhancing cognitive functions, particularly attention. I tested NooCube’s claim to improve problem-solving skills during a brainstorming session. I found that ideas flowed much more freely, and complex problems seemed that bit easier to tackle. This improvement might be attributed to Huperzine A [10], known for boosting alertness and mental clarity. Memory retention, often a challenge in information-heavy tasks, seemed improved. I found myself recalling intricate details from earlier meetings and conversations with surprising ease, potentially due to the effects of Vitamin B12 [11], which supports healthy nerve cells and cognitive function. Usually, extensive screen time results in eye strain for me by the end of the day. However, while using NooCube, I did find that screen fatigue was noticeably reduced, possibly due to the inclusion of LuteMax 2020 [12]. NooCube promises science-backed ingredients, and in my experience it certainly seemed to confirm this. For instance, Alpha GPC [13], found in the supplement, is known to enhance memory and cognitive function. Overall, my experience with NooCube was overall a very positive one. The synergy of it’s diverse ingredients and their combined cognitive benefits was evident in everyday tasks, from clearer decision-making to reduced fatigue. While it doesn't replace a balanced lifestyle, it certainly serves as an effective complement for me.
Alpha Brain
As I’ve suggested already, I was extremely keen to test Alpha Brain and put it’s amazing claims to the test. The idea of achieving exceptional mental clarity and focus is undeniably attractive for someone like me. These were the expectations I had when trying Alpha Brain. Anna, a friend of mine, shared an experience many of us can relate to. She remembered her university days when she could read extensively without losing focus. So I asked her to give this product a try as well. In short, I’m sorry to say that unfortunately Alpha Brain didn't bring back those days! I found that while there were moments of increased concentration, they were inconsistent. Anna felt the same as me. The product claims to help users become so absorbed in tasks that everything else fades away, but in my tests, these instances were rare. I felt that examining Alpha Brain's ingredient profile might provide some insight. The product uses proprietary blends, such as Onnit Flow Blend, Onnit Focus Blend, and Onnit Fuel Blend, making it hard to determine the exact amounts of each ingredient. This raises a crucial question for me and one that is common to ask in this industry: are these ingredients present in quantities that are proven to be really effective? Take Bacopa Monnieri, for example, a traditional herb known for cognitive enhancement. The recommended daily dose is typically between 300-450 mg [14]. However, within Alpha Brain's blends, it's unlikely that Bacopa Monnieri is present in an effective dose, given it shares the blend with other ingredients. Vinpocetine is another example. Effective doses start at 15mg [15], but given the Onnit Fuel Blend's total of 65 mg, which also includes L-Leucine and Pterostilbene, the individual Vinpocetine amount cannot be established from the blend total. Alpha Brain's goal to enhance alpha brain wave production and support neurotransmitter activity is obviously very appealing. The emphasis on acetylcholine production, a neurotransmitter essential for cognitive function [16], is commendable for sure. However, without clear dosages, there's a distinct lack of transparency. For me, proprietary blends aren't necessarily a problem; they can protect a company's unique formula. But for consumers, especially those familiar with nootropics like myself - transparency is crucial. Alpha Brain's aim to help users achieve "the zone" is admirable, but my experience was mixed. The lack of clear ingredient dosages compared to known effective ranges suggests room for improvement. Hopefully, future versions will consider these points.
Pros and Cons of NooCube:
Pros:
The ingredients span a broad spectrum: NooCube boasts a comprehensive list of ingredients, which include well-researched nootropics like Bacopa Monnieri, L-theanine, and choline.
The ingredients are supported by scientific studies: Most of NooCube's components have been researched extensively, and some have been shown to provide cognitive benefits [17,18].
The promise of protection from screen fatigue: The inclusion of LuteMax 2020 aims to shield the eyes from the fatigue caused by prolonged exposure to electronic screens [19].
Brain fog reduction claim: Ingredients like L-tyrosine have been associated with alleviating symptoms of fatigue-related brain fog [20].
Can boost memory and alertness: With components like Bacopa Monnieri, NooCube may enhance memory recall and mental alertness [21].
Has comprehensive vitamin support: The inclusion of vital vitamins, such as Vitamin B1, B7, and B12, ensure support for overall brain health.
Support for neurotransmitter production: Ingredients like choline play a crucial role in the production of acetylcholine, a significant neurotransmitter for cognitive function [22].
Cons:
Requires consistent usage to experience the benefits: For optimal results and to truly experience the cognitive benefits, NooCube requires consistent and regular intake. This means users can't expect significant improvements from sporadic or occasional use [23].
It’s only available from the manufacturer: NooCube is exclusively available for purchase directly from the manufacturer's website.
Pros and Cons of Alpha Brain:
Pros:
Celebrity endorsements: The product has been heavily endorsed by celebrities, particularly Joe Rogan, which has increased its visibility and popularity.
Ingredients profile is interesting: The supplement uses a range of natural ingredients, herbs, and vitamins known for their cognitive enhancing properties.
Cons:
The ingredients dosages are not clear : The use of proprietary blends obscures the exact amounts of individual ingredients, making it challenging to ascertain its efficacy and compare it to clinical studies.
Limited effects when tested: I did not experience the pronounced effects promoted by the brand. The real-world efficacy can therefore be suggested as variable.
The ingredient levels are questionable: Due to the low overall milligram amount in their proprietary blends, it's unclear if many of the ingredients are present in clinically effective dosages.
The hype vs. the reality: Given it’s celebrity endorsements and heavy marketing, could this just be hype? I certainly did not experience the dramatic results promised and the same goes for my friend Anna who also participated in the test.
Ingredients and evidence
NooCube:
LuteMax 2020, Bacopa Monnieri (250mg), Panax Ginseng 200:1 Concentrate (20mg), Pterostilbene (140mcg), Resveratrol (14.3mg), L-theanine (100mg), L-tyrosine (250mg), Choline (250mg), Cat’s claw 4:1 Concentrate, Vitamin B1 (1.1mg), Vitamin B7 (50mcg), Vitamin B12 (2.5mcg)
NooCube stands out from other nootropics with it’s broad range of generously dosed ingredients. Each ingredient, with varying degrees of scientific backing, contributes to the cognitive enhancement potential of the product.
Firstly, LuteMax 2020, a trademarked ingredient, is widely studied for it’s potential in protecting the eyes from blue light, commonly emitted from electronic devices [24]. It’s inclusion addresses the increasing screen fatigue in the digital age, ensuring that cognitive enhancement doesn't come at the cost of visual health.
A cornerstone in traditional Ayurvedic medicine, Bacopa Monnieri at 250mg in NooCube, is a renowned cognitive enhancer [25]. Clinical trials show significant memory-enhancing effects, especially when consumed consistently over several weeks [26]. The 250mg dosage aligns well with some clinical trial dosages, suggesting potential for efficacy here.
A lesser-known compound, Pterostilbene, is a potent antioxidant, believed to possess neuroprotective properties [27,28]. It’s dosage in NooCube is modest, and I feel that more research is required to determine it’s ideal concentration for cognitive enhancement. Similarly, Resveratrol is often hailed for it’s anti ageing properties and has shown potential in supporting brain health and function [29].
The calming amino acid, L-theanine, commonly found in tea, synergizes well with L-tyrosine [30]. These amino acids might support mood, reduce stress, and boost cognitive function respectively, with their inclusion in NooCube aiming for a balanced nootropic effect [31,32].
Cat's claw is a traditional remedy with cognitive benefits, although the scientific literature on ideal dosages and efficacy remains slightly unclear [33]. NooCube's B-vitamin complex – Vitamin B1, B7, and B12 – plays a pivotal role in energy production and neural function, ensuring that the brain operates optimally.
Overall I found that NooCube uses a broad spectrum of ingredients and it is evident that most, but not quite all, align precisely with clinically suggested dosages. My view is that the synergistic combination and the rationale behind the formulation feels like a very well rounded approach to cognitive enhancement.
Alpha Brain:
Vitamin B6 (Pyridoxine HCl), Onnit Flow Blend (650 mg): This proprietary blend consists of Bacopa Monniera Extract, Cat's Claw Extract (AC-11), Huperzia Serrata Extract, and Oat Straw Extract. Onnit Focus Blend (240 mg): This blend includes Alpha GPC, Bacopa Monniera, and Huperzia Serrata. Onnit Fuel Blend (65 mg): This blend comprises L-Leucine, Vinpocetine, and Pterostilbene. L-Tyrosine, L-Theanine, Phosphatidylserine, Alpha GPC, Bacopa Monniera, Huperzia Serrata, Oat Straw Extract, Vinpocetine, Pterostilbene.
Alpha Brain has positioned itself as a forerunner in the nootropics field, owing largely to its high profile paid celebrity endorsements. However, I have a pressing concern from its reliance on proprietary blends, which essentially mask the exact dosages of individual components. This becomes especially concerning for me when I crunch the numbers and contrast them with established clinical doses. To provide clarity, I have assessed the mathematics of what's really in Alpha Brain's formulation.
Bacopa Monnieri is included in the Onnit Flow Blend, which totals 650mg. Research consistently indicates an effective daily dose of Bacopa to be around 300mg for cognitive benefits [34]. Assuming an optimal dosage, this would leave only 350mg to be divided among the other constituents of the blend, such as Cat's Claw Extract, Huperzia Serrata, and Oat Straw Extract. Given that each of these also has clinically recommended dosages that often exceed this remaining amount, it becomes clear that not all ingredients can be dosed effectively. So, this is a real concern for me.
The Onnit Focus Blend further compounds this issue. Totalling 240mg, it encompasses Alpha GPC, Bacopa Monniera, and Huperzia Serrata. For Alpha GPC to be effective, doses usually range from 300mg to 600mg [35]. Even at the lowest end of this range, the 240mg total blend would be insufficient, not to mention the inclusion of other ingredients.
Similarly, the Onnit Fuel Blend, at 65mg, contains Vinpocetine. Clinical studies often recommend a dosage of 15-30mg of Vinpocetine for cognitive enhancements [36]. If we were to use the upper limit, only 35mg would remain for L-Leucine and Pterostilbene. Given that Pterostilbene's recommended doses start from around 50mg [37], the math simply doesn't add up for optimal efficacy.
What my analysis shows really is a fundamental quandary. The proprietary blends, by their very structure, make it impossible to establish every individual ingredient amount. This isn't merely speculative; it's grounded in simple arithmetic and underpinned by clinical studies. While Alpha Brain's ingredient seems impressive at first glance, the undisclosed breakdown within the proprietary blends, when viewed in light of clinical dosage recommendations, raises significant concerns to me about the product's potential effectiveness.
Potential side effects:
Here I outline what sort of side effects I would expect a user to have based on the ingredients analysis. Note, I did not experience any of these myself but these could occur in my view.
NooCube:
Bacopa Monnieri, at a dosage of 250mg, is generally considered safe. However, some users might experience gastrointestinal issues such as diarrhoea, stomach cramps, or nausea [38]. Its long-term safety beyond 12 weeks of consistent use has not been extensively studied.
Huperzine A is not listed in the current NooCube formula. Side effects attributed to it should not be presented as current NooCube effects.
Pterostilbene is generally considered safe in small amounts. But at high dosages, users might observe an increase in cholesterol levels and a potential increase in the risk of developing some chronic diseases [40].
Resveratrol, despite its potential heart-health benefits, might lead to side effects such as nausea, stomach cramps, and diarrhoea [41].
L-Theanine and L-Tyrosine are typically well-tolerated. However, some people could encounter headaches or dizziness with L-Theanine [42], or nausea, headache, fatigue, and heartburn with L-Tyrosine [43].
The current NooCube formula uses choline from choline bitartrate, rather than Alpha GPC. These forms should not be treated as interchangeable when comparing evidence or tolerability.
Oat Straw is generally benign, but in rare cases, might result in digestive discomfort [45].
Cat’s Claw, while primarily used for its immune-boosting properties, can occasionally result in dizziness, nausea, or diarrhoea in some people [46].
Lastly, the vitamins: Vitamin B1, B7, and B12, when consumed within the recommended range, are generally safe. But excessive vitamin intake, beyond what's found in NooCube, can lead to imbalances or mild reactions [47].
Alpha Brain:
Vitamin B6 (Pyridoxine HCl) in standard amounts is benign. However, prolonged overconsumption might result in nerve damage, manifesting as tingling or numbness [48].
The Onnit Flow Blend has:
Bacopa Monnieri, which can cause gastrointestinal issues such as diarrhoea or stomach cramps [49].
Cat’s Claw (AC-11), which might occasionally cause dizziness or nausea [50].
Huperzia Serrata, which, while aiding memory, can lead to side effects such as nausea, diarrhoea, or vomiting [51].
Oat Straw Extract is generally safe but could cause digestive discomfort in rare instances [52].
The Onnit Focus Blend comprises:
Alpha GPC, which at high doses might lead to heartburn, headache, or insomnia [53].
Bacopa Monnieri and Huperzia Serrata, already covered in the Flow Blend.
The Onnit Fuel Blend includes:
L-Leucine, generally safe, but excessive intake can cause vitamin B3 and B6 deficiencies [54].
Vinpocetine enhances cerebral blood flow, but might cause some stomach pain, nausea, sleep disturbances, headache, dizziness, nervousness, or flushing of the face [55].
Pterostilbene, as mentioned previously, is safe in small amounts but in higher dosages might increase cholesterol levels [56].
L-Tyrosine could lead to side effects like nausea, headache, or fatigue [57]. L-Theanine is usually well-tolerated, but some might experience headaches or dizziness [58]. Phosphatidylserine is generally safe, yet can cause stomach upset or insomnia, especially in doses over 300 mg [59].
In Conclusion:
Alpha Brain’s branding is prominent, but I would still look closely at the ingredient amounts when assessing the product.
NooCube is developed with a stronger scientific approach: It emphasizes a transparent, scientific approach to formulation, allowing each ingredient's dosage to be checked rather than assuming it is well qualified from scientific research.
Alpha Brain’s main issue is not declaring ingredient quantities: Proprietary blends mask exact ingredient quantities, so the individual amounts cannot all be assessed.
NooCube has a comprehensive formulation: It features a broad range of individually disclosed ingredients for a wide variety of cognitive enhancements, from memory to focus.
My verdict is to give NooCube a firm recommendation: NooCube outperformed Alpha Brain in my testing, offering a noticeable, sustained cognitive boost.
I feel that I can trust NooCube: NooCube's claims are not only evidence-backed but were also experienced firsthand, making it my top recommendation.
Final thoughts: NooCube vs. Alpha Brain
It’s very clear to me that the world of nootropics offers many options, with NooCube and Alpha Brain being among the most popular on the market today. A closer look at their formulations certainly highlights their respective strengths and weaknesses. I would conclude that one major drawback of Alpha Brain is it’s use of proprietary blends [60]. The Onnit Flow, Focus, and Fuel blends contain a variety of nootropic compounds, but the exact dosages of each ingredient are not disclosed by the brand. This lack of transparency makes it very difficult to evaluate the effectiveness and potential side effects, especially when the total blend amount suggests that many ingredients are unlikely to be present in clinically effective doses [61]. NooCube is different altogether. The brand clearly lists its ingredient dosages. For example, it contains 250mg of Bacopa Monnieri and 250mg of L-tyrosine, which align with clinical studies supporting cognitive function and stress resistance [62,63]. The combination of L-theanine and L-tyrosine helps improve focus and promote a calm state of mind [64], resulting in enhanced cognitive performance. My experience with NooCube was also significantly more positive. The well-defined formula appeared to enhance my cognitive performance, including better memory, attention, and mental clarity [66]. Ingredients like LuteMax 2020, Resveratrol, and Vitamin B12 provided a well-rounded and sustained cognitive boost [65-67]. Whilst both supplements offer cognitive benefits, NooCube stands out for me for it’s transparency and comprehensive formulation. More importantly, it delivered noticeable and significant cognitive improvements for me, far more than Alpha Brain in comparison. For those looking for a consistent and reliable cognitive enhancement, I would recommend NooCube over Alpha Brain.
For readers considering an alternative to both, ThinkEase is my preference for a broader, caffeine-free formula with individually disclosed amounts. It combines 300mg Bacopa Monnieri, 250mg Citicoline, 200mg L-Theanine and 550mg Lion’s Mane, among other ingredients. This is a formula-based recommendation, separate from the NooCube and Alpha Brain testing reported above.